The two stars have already sparked a major pop incident on social media.

Madonna’s current wave of success has been a joy to behold, from the rave reviews for her latest albums Confessions II to her return to the UK top 10 thanks to her long-awaited collaboration with fellow music icon Kylie Minogue.

But it seems the Queen of Pop is not done yet.

Over the weekend, the Grammy winner posted a TikTok video of herself pensively listening to the Confessions II cut "L.E.S. Girl", which brings the album to a melancholic ending.

“Thinking about Charli…” she captioned the post, with Charli XCX then popping up in the comments section shortly afterwards.

“Wait… I got something I wanna talk about,” the British singer-songwriter wrote, in a nod to the lyrics of Madonna’s recent Sabrina Carpenter duet "Bring Your Love", which has become something of a meme in recent weeks.

The two singers’ exchange has led many fans to speculate that they might be about to cross musical paths, potentially on a new remixed version of "L.E.S. Girl".

madonna and charli collab is finally happening pic.twitter.com/1bg9dp3NIF

need an afterhours remix album so bad https://t.co/6vvv4VmSm7

THIS IS FCKIN MAJOR, THE MOST IMPORTANT EVENT IN HISTORY IS ABOUT TO HAPPEN https://t.co/KT1dWowLM7 https://t.co/G0lPWKZWXS

Perfect song for charli to be on too! https://t.co/xisyx1Zn5h

The pop girlies are cooking again and nobody is ready. 😭

HuffPost UK has contacted Madonna and Charli’s teams for comment.

Over the summer, Charli and Madonna were both pictured on the front row of Saint Laurent’s show at Paris Fashion Week, where they were seen laughing and smoking together.

After that, Charli told Nick Grimshaw for Radio 6 Music that she and the Like A Prayer singer kept running into each other, to the point their Paris trip felt like a “mini break together”.

Charli enthused: “She’s fab. She’s just so cool, and so interested in really talking about the music that she makes, and how, and why. I found it very inspiring to hang out with her.”

She also praised Madonna’s “wealth of songs” and “high” taste level, revealing the first Madonna song she “fell in love with” was the 2003 single Hollywood, taken from the album American Life.

Interestingly, earlier in the year, it looked like there may have been some mild beef between Charli and Madonna, after the Von Dutch singer claimed during a now-infamous British Vogue interview (and, subsequently, on her divisive single "Rock Music") that she thinks the “dance floor is dead”.

“If your dance floor feels dead, maybe you’re playing the wrong music,” Madonna cryptically wrote on Instagram shortly afterwards.