About three days into his role as the titular character’s voice in Howard the Duck, Robin Williams quit out of frustration because he was “being handcuffed in order to match the flapping duck’s bill.” The puppet’s mouth movements had already been filmed to match the puppeteers’ bland delivery of the lines, essentially rendering the comedian’s iconic improvisation style impossible.

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She told MTV, "I just felt the project wasn't 100% there. I feel [that] production-wise everything just felt a little rushed. And I think because she's someone I admire and I love so much, it can't be done halfway, or not to the standards I think it should be done at, so I just decided not to do it."

In a statement, the Alzheimer's Association said, "[This organization] is appalled that anyone would plan to develop a film that satirizes an individual living with Alzheimer's or another dementia. Would filmmakers consider using a fatal form of cancer or another deadly disease for comedy? It's time to stop this forever."

She told Variety, "That was not a space that I should have taken up. And it was so exhilarating to see it fulfilled by people who should have been a part of it and who deserved it and who were right for it. I just wasn't."

Chip Zien, who replaced him, told the Hollywood Reporter, "What I was told was by the third day, Robin said, 'I can't do this. It is insane. I can't get the rhythm of this. I am being confined...' So, on Memorial Day 1985, I got a call from my agent, who said, 'You have to get right to the airport! Robin Williams just quit, and you're now Howard the Duck. You need to get there tonight. There is a ticket waiting for you at the counter.' I was incredibly excited."

On the Hollywood Reporter’s Dramatic Actress Roundtable, she said, "So, that coming up, I was like, 'I can't.' I did a minimal amount, and I'm pigeonholed for life, so me saying yes to [Fifty Shades], where the entire thing is about sensuality and sex and being naked and all of that stuff, I was just like, 'No way am I going to voluntarily walk into that situation and then never be able to look someone in the eye.'"

PARIS, FRANCE - JANUARY 25: (EDITORIAL USE ONLY - For Non-Editorial use please seek approval from Fashion House) Anne Hathaway attends the Valentino Haute Couture Spring Summer 2023 show as part of Paris Fashion Week on January 25, 2023 in Paris, France. (Photo by Marc Piasecki/WireImage)

She told Allure, "And by the way, I could pop a kid out and think, 'Oh, well, I really should have done that movie.'"

He recommended David Carradine, who ended up getting the part.

The part indeed went to Demi, becoming their breakout role.

She told Newsweek that her criticism was of Hollywood, not Halle Berry, who won an Oscar for the role.

Al Pacino was, of course, a perfect fit for the part.

She told Adweek, "I remember being like, 'Oh, they think that this is a fun thing for me, and it's so insulting.' Those were some of the moments where I was like, 'Is this what it is in Hollywood? I think I might have to write for myself...'"

So, she co-created the Hulu series Shrill and cast herself as the lead.

In a Reddit AMA, she said, "I felt uncomfortable because I would have had to go on a horse and he would have touched me up and shit. Once they told me what was entailed, I said no thanks."

He told Vulture, "I felt like it made heroin use attractive. For me, it's not just my character. It's, 'What is the whole thing saying?'"

She told ComicBook.com, "I remember Jennifer Lawrence talking about once, how long it took her to get blue [for X-Men]. And I was like, 'That seems like hell on earth,' because then you get to set, and you're only there for a couple hours, and then you have to take everything off. And that was literally the reason."

However, she later told the Hollywood Reporter's Awards Chatter podcast, "I didn’t want to be part of the first Marvel movie that bombed. ... The script was great, it was all based in not wanting to be 'that guy.' Because if you are the star of a giant movie like that, and it bombs, Hollywood does not forgive you. I've seen that happen to people and it was a giant, giant fear and I thought, is it worth it?"