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We just covered the 12 Best Stocks to Invest In According to Jim Simons’ Renaissance Technologies and United Therapeutics Corporation (NASDAQ:UTHR) ranks 1st on this list.

United Therapeutics Corporation (NASDAQ:UTHR) is a long-term holding in the 13F portfolio of Renaissance Technologies. The fund first disclosed a stake in the company back in the fourth quarter of 2010. This position comprised 261,000 shares. By the middle of 2012, this position had been sold off completely. A new position in the company was then opened in the fourth quarter of 2014. Since then, the stock has featured consistently in the portfolio of the fund. Filings for the first quarter of 2026 show that the fund owned just under 1.8 million shares in the firm, down more than 6% compared to filings for the fourth quarter of 2025.

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United Therapeutics Corporation (NASDAQ:UTHR) is expanding into Idiopathic Pulmonary Fibrosis (IPF), a progressive, fatal lung disease with almost no effective treatments. Following the blockbuster success of the Phase 3 TETON-2 study, the latest clinical data from the TETON studies showed that nebulized Tyvaso achieved highly significant improvements in lung function over 52 weeks. Management noted that physicians are highly impressed with the TETON data, and the company is preparing major NDA submissions to the FDA. If approved, Tyvaso will be the first inhaled anti-fibrotic treatment for IPF.

While we acknowledge the potential of UTHR as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you're looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock.

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