CAIRO (AP) — Iran responded Sunday with threats of its own, a day after President Donald Trump warned the United States will “obliterate” Iran’s power plants if Tehran fails to fully open the Strait of Hormuz in 48 hours and Iranian missiles struck two cities near Israel’s main nuclear research center, injuring dozens and shattering apartment buildings.

The developments signaled the war in the Middle East, now in its fourth week, was moving in a dangerous new direction.

Sirens blared across Israel as Iran launched new barrages Sunday. In the country’s south, residents faced the devastation in the cities of Dimona and Arad. In northern Israel, a man was killed in a strike by the Lebanese militant Hezbollah group.

Israeli Prime Minister Benjamin Netanyahu toured Arad and said it was a “miracle” that no one was killed by the blast, which heavily damaged several buildings. But he said that if all residents had rushed to shelters, no one would have been hurt and urged all to heed the sirens.

Trump said on Saturday that he would give Iran 48 hours to open the vital Strait of Hormuz or face a new round of attacks. He said the U.S. would destroy “various POWER PLANTS, STARTING WITH THE BIGGEST ONE FIRST!”

He may have meant the Bushehr nuclear power plant, Iran’s biggest, which was already hit last week, or Damavand, a natural gas plant near Tehran, Iran’s capital.

In turn, Iran warned early Sunday that any strike on its energy facilities would prompt attacks on U.S. and Israeli energy and infrastructure assets — specifically information technology and desalination facilities — in the region, according to a statement citing an Iranian military spokesperson carried by state media and semiofficial outlets.

The Strait of Hormuz connects the Persian Gulf to the Indian Ocean and is a critical pathway for the world’s flow of oil. Attacks on commercial ships and threats of further strikes have stopped nearly all tankers from carrying oil, gas and other goods through the passage, leading to cuts in output from some of the world’s largest oil producers, because their crude has nowhere to go.

Seyed Ali Mousavi, Iran’s envoy to the International Maritime Organization, said in remarks carried by two Iranian news agencies that navigating the strait is possible for “everyone except enemies” — indicating Tehran would determine which vessels are allowed passage. Iran has already approved the passage of ships through the waterway to China and elsewhere in Asia.

Israel’s military said it was not able to intercept missiles that hit Dimona and Arad on Saturday, the largest cities near the Negev Desert nuclear center. It was the first time Iranian missiles penetrated Israel’s air defense systems in the area.

“If the Israeli regime is unable to intercept missiles in the heavily protected Dimona area, it is, operationally, a sign of entering a new phase of the battle,” Iran’s Parliament Speaker Mohammad Bagher Ghalibaf said on X.

Rescue workers said at least 64 people were taken to hospitals after the direct hit in Arad. Dimona is about 20 kilometers (12 miles) west of the nuclear research center and Arad around 35 kilometers (22 miles) north.

Israel’s hard-line national security minister, Itamar Ben-Gvir, visited Arad on Sunday, saying that Israel is in a “historic battle” against Iran and that it must “continue until victory.”

Israel is believed to possess nuclear weapons, though it doesn’t confirm or deny this. The U.N. nuclear watchdog said on X it had not received reports of damage to the Israeli center or any abnormal radiation levels.

Tehran’s main nuclear enrichment site at Natanz was hit earlier on Saturday. Israel denied responsibility for the attack and the Iranian judiciary’s official news agency, Mizan, said there was no leakage.

The Pentagon declined to comment on the strike on Natanz, which was also hit in the first week of the ongoing war and in the 12-day war last June.

The U.N. watchdog — the International Atomic Energy Agency — has said the bulk of Iran’s estimated 972 pounds (441 kilograms) of enriched uranium is elsewhere, beneath the rubble at its Isfahan facility.

The U.S. and Israel have offered shifting rationales for the war, from hoping to foment an uprising that topples Iran’s leadership to eliminating its nuclear and missile programs and its support for armed proxies. There have been no signs of an uprising, while internet restrictions limit information from Iran.

The war’s effects are felt far beyond the Middle East, raising food and fuel prices.

So far in Iran, the death toll in the war has surpassed 1,500, the state broadcaster reported Saturday, citing the health ministry. In Israel, 15 people have been killed by Iranian missiles. Four others have died in the occupied West Bank. At least 13 U.S. military members have been killed, along with well over a dozen civilians in Gulf nations.

Hezbollah said it was behind a strike on Sunday that killed a man in the northern Israeli town of Misgav Am in what the Israeli military said “seemed to be” a rocket attack. Israeli medics said they found the man dead in his car and released a video showing two vehicles ablaze.

Hezbollah, an ally of Iran, launched strikes on Israel soon after the U.S.-Israeli attack on Iran started on Feb. 28, saying it was in retaliation for the killing of Iran’s Supreme Leader Ayatollah Ali Khamenei. Israel struck back, bombarding Lebanon and targeting Hezbollah in deadly airstrikes, expanding its presence in southern Lebanon and amassing more troops near the border.

Lebanese authorities say Israel’s strikes have killed more than 1,000 people and displaced more than 1 million.

In Doha, six people were confirmed killed in a Qatari helicopter crash in the Persian Gulf nation’s territorial waters. One person was still missing from Saturday’s crash, which was blamed on a “technical malfunction.”

Qatar’s Defense Ministry said the dead included three Qatari forces and three Turkish nationals, including a military officer and two civilians. The missing person is a Qatari airman, it said.

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Metz reported from Ramallah, West Bank, and Debre from Beirut. Associated Press writers Jill Lawless in London and Melanie Lidman and Sam Mednick in Tel Aviv, Israel, contributed to this report.

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